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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bonedisorder

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 378-385 doi: 10.1007/s11684-017-0541-8

摘要：

The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease (CKD) to predict putative microRNA (miRNA) in CKD–mineral bone disorder (CKD–MBD) and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD–MBD was determined. Additionally, changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells. A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified. Furthermore, miRNA expression profiles were inferred, and computational analyses were performed with the imputed microRNA regulation based on weighted ranked expression and putative microRNA targets (IMRE) method to identify miRNAs associated with CKD occurrence. TLR4 and miR-146b levels were significantly associated with CKD–MBD. TLR4 levels were significantly downregulated, whereas pri-miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells. Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis, and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.

关键词： chronic kidney disease     microRNA     mineral bone disorder     uremia    

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 323-329 doi: 10.1007/s11684-009-0061-2

摘要： The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

关键词： early postmenopausal women     bone mineral density     exercise     effects    

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Translational application of neuroimaging in major depressive disorder: a review of psychoradiological

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

《医学前沿（英文）》 2021年 第15卷 第4期   页码 528-540 doi: 10.1007/s11684-020-0798-1

摘要： Major depressive disorder (MDD) causes great decrements in health and quality of life with increments in healthcare costs, but the causes and pathogenesis of depression remain largely unknown, which greatly prevent its early detection and effective treatment. With the advancement of neuroimaging approaches, numerous functional and structural alterations in the brain have been detected in MDD and more recently attempts have been made to apply these findings to clinical practice. In this review, we provide an updated summary of the progress in translational application of psychoradiological findings in MDD with a specified focus on potential clinical usage. The foreseeable clinical applications for different MRI modalities were introduced according to their role in disorder classification, subtyping, and prediction. While evidence of cerebral structural and functional changes associated with MDD classification and subtyping was heterogeneous and/or sparse, the ACC and hippocampus have been consistently suggested to be important biomarkers in predicting treatment selection and treatment response. These findings underlined the potential utility of brain biomarkers for clinical practice.

关键词： psychoradiology     major depressive disorder     MRI     biomarker    

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Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

《医学前沿（英文）》 2019年 第13卷 第2期   页码 160-188 doi: 10.1007/s11684-018-0629-9

摘要： Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration.

关键词： bone tissue engineering     stem cell     bone scaffold     growth factor     bone regeneration    

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Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder

OUYANG Shan, ZHANG Qinghua, QIAO Fuyuan

《医学前沿（英文）》 2007年 第1卷 第4期   页码 386-389 doi: 10.1007/s11684-007-0075-6

摘要： The aim of this study was to investigate the expression of hepatocyte growth factor (HGF) and Fas in placentas of uncomplicated pregnant women and those with hypertensive disorder complicating pregnancy (HDCP), and elucidate the possible relationship between HGF and apoptosis of trophoblasts. Reverse transcription-polymerase chain reaction (RT-PCR) was undertaken to examine the concentration of HGF mRNA and Fas mRNA obtained from 34 cases of HDCP and 30 cases of uncomplicated pregnancy. The expression of HGF mRNA in mild preeclampsia, severe preeclampsia and eclampsia cases was significantly lower than that in the uncomplicated cases (0.43±0.12, 0.38±0.09, 0.19±0.17 versus 0.67±0.19, <0.05), while the expression of Fas mRNA in mild preeclampsia, severe preeclampsia and eclampisa cases was significantly higher than that in the uncomplicated cases (1.58±0.26, 2.96±0.14, 5.98±1.17 versus 1.01±0.36, <0.05). For HGF mRNA and Fas mRNA, there was no difference between gestational hypertension cases and control cases. Decreased HGF mRNA or increased Fas mRNA was found along with the progress of HDCP. Negative correlation was found between the expressions of HGF and Fas. These results indicate that HGF inhibits the apoptosis mediated by Fas, and the reduced expression of HGF in HDCP may be responsible for the apoptosis of trophoblasts.

关键词： pregnancy     concentration     possible relationship     responsible     hepatocyte    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

《医学前沿（英文）》 2022年 第16卷 第6期   页码 896-908 doi: 10.1007/s11684-022-0944-z

摘要： Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting its essential role in tumorigenesis. Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize its associations with bone marrow niches. Results showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was related to prolonged overall survival (OS). Univariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factor. A prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-, 3-, and 5-year OS. Gene mutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was related to bone marrow niches. As for immunity, FGF13 was remarkably associated with T cell count, immune checkpoint genes, and cytokines. In addition, FGF13 overexpression substantially inhibited the growth and significantly induced the early apoptosis of AML cells. The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice. Overall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to the bone marrow microenvironment.

关键词： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 522-526 doi: 10.1007/s11684-016-0485-4

摘要：

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.

关键词： autograft     bone marrow stem cells     ulcerative colitis     cell therapy    

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Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0717-z

摘要： Bone grinding is an essential and vital procedure in most surgical operations. Currently, the insufficient cooling capacity of dry grinding, poor visibility of drip irrigation surgery area, and large grinding force leading to high grinding temperature are the technical bottlenecks of micro-grinding. A new micro-grinding process called ultrasonic vibration-assisted nanoparticle jet mist cooling (U-NJMC) is innovatively proposed to solve the technical problem. It combines the advantages of ultrasonic vibration (UV) and nanoparticle jet mist cooling (NJMC). Notwithstanding, the combined effect of multi parameter collaborative of U-NJMC on cooling has not been investigated. The grinding force, friction coefficient, specific grinding energy, and grinding temperature under dry, drip irrigation, UV, minimum quantity lubrication (MQL), NJMC, and U-NJMC micro-grinding were compared and analyzed. Results showed that the minimum normal grinding force and tangential grinding force of U-NJMC micro-grinding were 1.39 and 0.32 N, which were 75.1% and 82.9% less than those in dry grinding, respectively. The minimum friction coefficient and specific grinding energy were achieved using U-NJMC. Compared with dry, drip, UV, MQL, and NJMC grinding, the friction coefficient of U-NJMC was decreased by 31.3%, 17.0%, 19.0%, 9.8%, and 12.5%, respectively, and the specific grinding energy was decreased by 83.0%, 72.7%, 77.8%, 52.3%, and 64.7%, respectively. Compared with UV or NJMC alone, the grinding temperature of U-NJMC was decreased by 33.5% and 10.0%, respectively. These results showed that U-NJMC provides a novel approach for clinical surgical micro-grinding of biological bone.

关键词： micro-grinding     biological bone     ultrasonic vibration (UV)     nanoparticle jet mist cooling (NJMC)     grinding force     grinding temperature    

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Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma

《医学前沿（英文）》 2019年 第13卷 第2期   页码 189-201 doi: 10.1007/s11684-018-0664-6

摘要： Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.

关键词： hybrid polymer     bone regeneration     tissue engineering     biomaterials    

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Progress of three-dimensional macroporous bioactive glass for bone regeneration

Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU

《化学科学与工程前沿（英文）》 2012年 第6卷 第4期   页码 470-483 doi: 10.1007/s11705-012-1217-1

摘要： Bioactive glasses (BGs) are ideal materials for macroporous scaffolds due to their excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high bone bonding rates. Macroporous scaffolds made from BGs are in high demand for bone regeneration because they can stimulate vascularized bone ingrowth and they enhance bonding between scaffolds and surrounding tissues. Engineering BG/biopolymers (BP) composites or hybrids may be a good way to prepare macroporous scaffolds with excellent properties. This paper summarizes the progress in the past few years in preparing three-dimensional macroporous BG and BG/BP scaffolds for bone regeneration. Since the brittleness of BGs is a major problem in developing macroporous scaffolds and this limits their use in load bearing applications, the mechanical properties of macroporous scaffolds are particularly emphasized in this review.

关键词： bioactive glass     biopolymer     bone regeneration     macroporous scaffolds     tissue engineering    

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Thermochemical pretreatment of meat and bone meal and its effect on methane production

Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 300-306 doi: 10.1007/s11783-009-0031-6

摘要： Since the solubilization of meat and bone meal (MBM) is a prerequisite in many MBM disposal approaches, enhancement of the solubilization by means of thermochemical pretreatment was investigated in this study at two temperatures (55°C and 131°C) and six sodium hydroxide (NaOH) concentrations (0, 1.25, 2.5, 5, 10 and 20g/L). The MBM volatile solid (VS) reduction ratio was up to 66% and 70% at 55°C and 131°C, respectively. At the same temperature, the VS reduction ratio increased with the increase in the dosage of NaOH. The study on the methane (CH) production potential of pretreated MBM shows that the addition of NaOH at 55°C did not cause the inhibition of the succeeding CH production process. However, CH production was inhibited by the addition of NaOH at 131°C. The CH production potential was in the range of 389 to 503mL CH/g VS MBM and 464 to 555mL CH/g VS MBM at 55°C and 131°C, respectively.

关键词： thermochemical pretreatment     meat and bone meal     solid reduction     solid solubilization     methane production potential    

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矿物浮选吸附平衡模型构建与应用：精准解析矿物 表面离子 / 药剂特征吸附

高雅,付心壮,韩海生,王丽,岳彤,孙伟

《中国工程科学》 2023年 第25卷 第6期   页码 248-258 doi: 10.15302/J-SSCAE-2023.07.020

摘要：

矿物浮选吸附平衡模型是准确描述矿物浮选过程中所涉及的矿物表面离子 / 药剂吸附平衡的数学模型，首次实现了矿物表面位点与浮选药剂吸附作用亲和性的量化解析。传统浮选理论对矿物表面作用位点缺乏科学描述，难以阐明浮选药剂的吸附作用能力及平衡状态，新浮选药剂体系开发多以“试错法”“复配法”等经验性方法为主。药剂选择性吸附作为浮选作业的核心机制，若不能准确预测其在各矿物表面的吸附行为，将严重限制浮选工艺智能化控制的发展。本文详细论述了矿物浮选吸附平衡模型的构建原理，以赤铁矿 ‒ 石英和一水硬铝石 ‒ 高岭石两个浮选体系为例，通过对少量实验数据的拟合计算，解析出矿物表面活性位点密度Ns、加 / 去质子反应常数Kt1/Kt2、药剂吸附常数Kf等矿物浮选特征常数。将解析的矿物浮选特征常数代入到平衡模型中，预测出各条件下矿物表面电性、离子及浮选药剂的吸附量，通过零电点、实验及测试等方法验证了可靠性，形成了矿物浮选过程预测系统的内核算法。该算法对各条件下每种矿物药剂吸附的初步准确预测，可在一定程度上反映其可浮性趋势，有助于缩短浮选工艺开发周期，对矿物表面药剂吸附机理研究、浮选药剂分子设计、浮选工艺流程优化及智能控制等具有重要意义。

关键词： 矿物加工；浮选机理；矿物浮选吸附平衡模型；可浮性预测；矿物浮选特征常数    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

《医学前沿（英文）》 2022年 第16卷 第4期   页码 551-573 doi: 10.1007/s11684-022-0928-z

摘要： Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

关键词： HCC     bone     osteotropism     clinical     basic researches     advances    

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Relationship between the development of energy and mineral resources and ecological conservation redline

Dawei ZHANG

《工程管理前沿（英文）》 2019年 第6卷 第4期   页码 557-563 doi: 10.1007/s42524-019-0077-5

摘要： From a philosophical point of view, this study discusses the dialectical relationship between the development of energy and mineral resources and the ecological conservation redline. We propose that the ecological conservation redline and the development of energy and mineral resources should be guided by ecological civilization construction, that is, the energy and mineral resources should be rationally developed under the condition that the ecological environment is protected. This study analyzes the influence of the development of energy and mineral resources on the ecological environment. The handling of mining rights within the ecological conservation redline based on the law and the reduction of the influence of the development of energy mineral resources on the ecological environment by science and technology are presented. The environmental assessment system and technical standards for energy and mineral development are suggested to implement policies and measures for the disposal of mining rights within the redline and facilitate technological innovations of ecological conservation for energy and mineral development. Hence, a coordinated development between the ecological conservation redline and the development of energy and mineral resources can be promoted.

关键词： ecological conservation redline     development of energy and mineral resources     coordinated development    

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A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate

Meng GUO, Yiqiu TAN, Linbing WANG, Yue HOU

《结构与土木工程前沿（英文）》 2018年 第12卷 第2期   页码 248-259 doi: 10.1007/s11709-017-0422-x

摘要： The interface between asphalt binder and mineral aggregate directly affects the service life of pavement because the defects and stress concentration occur more easily there. The interaction between asphalt binder and mineral aggregate is the main cause of forming the interface. This paper presents an extensive review on the test technologies and analysis methods of interfacial interaction, including molecular dynamics simulation, phase field approach, absorption tests, rheological methods and macro mechanical tests. All of the studies conducted on this topic clearly indicated that the interfacial interaction between asphalt binder and mineral aggregate is a physical-chemical process, and can be qualitatively characterized by microscopical technique (such as SEM and AFM), and also can be quantitatively evaluated by rheological methods and interfacial mechanical tests. Molecular dynamics simulation and phase field approach were also demonstrated to be effective methods to study the interfacial behavior and its mechanism.

关键词： Asphalt binder     Mineral aggregate     Interfacial behavior     Multiscale    

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标题 作者 时间 类型 操作

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bonedisorder

null

期刊论文

Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

期刊论文

Translational application of neuroimaging in major depressive disorder: a review of psychoradiological

Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal

期刊论文

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

期刊论文

Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder

OUYANG Shan, ZHANG Qinghua, QIAO Fuyuan

期刊论文

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

期刊论文

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated

null

期刊论文

Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant

期刊论文

Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma

期刊论文

Progress of three-dimensional macroporous bioactive glass for bone regeneration

Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU

期刊论文

Thermochemical pretreatment of meat and bone meal and its effect on methane production

Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,

期刊论文

矿物浮选吸附平衡模型构建与应用：精准解析矿物 表面离子 / 药剂特征吸附

高雅,付心壮,韩海生,王丽,岳彤,孙伟

期刊论文

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

期刊论文

Relationship between the development of energy and mineral resources and ecological conservation redline

Dawei ZHANG

期刊论文

A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate

Meng GUO, Yiqiu TAN, Linbing WANG, Yue HOU

期刊论文